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Eccrine poroma Pathology

Eccrine Poroma. Poromas have a predilection for the palms and soles but can arise at any site including trunk and head and neck region. Clinically, poroma appears skin colored or erythematous and may resemble a pyogenic granuloma. Microscopically, it is characterized by anastomosing trabeculae of squamous cells with multiple connections to the. The most distinguishing feature of eccrine poroma is a monotonous proliferation of bland-appearing, round to polygonal squamoid cells with abundant glycogen-rich cytoplasm (Fig. 49-19). The cells have round, basophilic nuclei and inconspicuous intercellular bridges Eccrine poroma can mimic benign and malignant melanocytic and non-melanocytic lesions. To date, little is known about the dermoscopic features of this condition. Seven histopathologically proven cases of eccrine poroma were examined using dermoscopy by three independent dermatologists The nodular appearance at low magnification reflects the nodular clinical appearance poromas often have. Interconnecting bands epithelial cells growing down into the dermis are seen with multiple attachments to the epidermis. The interconnecting bands lack the infiltrative pattern seen in porocarcinomas. slide 1 of 12

Eccrine Poroma Dermatopathology - Cornell Universit

  1. Poroma is a rare benign dermatologic neoplasm. Eccrine poroma redirect here
  2. Immunohistochemistry of eccrine poroma and porocarcinoma--more than acrosyringeal tumors? Sweat gland tumors have been classified according to their presumed physiological counterpart of the sweat apparatus. Both benign poroma and malignant porocarcinoma are thought to be acrosyringeal tumors
  3. These lesions are typically located on palmar or plantar skin, but may occur in any area where eccrine glands are present. Clinically, a poroma is described as a sharply demarcated 2-12 mm papule or nodule, usually flesh or pink in color, though a pigmented variant has been reported (Figure 1). Figure 1. Poroma on medial foot

Poromas are a group of benign growths of poroid differentiation, i.e. derived from cells of the terminal duct and connected to the epidermis. They can be of either eccrine or apocrine lineage. They may present as papules (bumps), plaques (thickened patches like seborrhoeic keratoses), or nodules (lumps). Names used to describe poromas include Eccrine poromas are benign cutaneous tumors that generally arise from the intraepidermal eccrine sweat duct unit. They occur most often during middle age or later, but have been noted to develop as early as 15 years of age. Eccrine poromas present as firm papules, plaques, or nodules, and may be flesh-colored to red Porocarcinoma Porocarcinoma is a rare malignant skin tumour that has an aggressive behaviour. It is also known as eccrine porocarcinoma (abbreviated EPC) and malignant eccrine poroma Visual survey of surgical pathology with 11134 high-quality images of benign and malignant neoplasms & related entities. Eccrine & Apocrine Tumors Focused Eccrine & Apocrine Tumors with stained slides of pathology

Abstract Pinkus initially described eccrine poroma as a benign neoplasm of the acrosyringium. The tumor, often consisting of broad anastamosing bands, arises from the epidermis and extends downward into the dermis Eccrine porocarcinoma is a rare type of skin cancer arising from sweat glands. Specifically, it is a malignancy of the eccrine sweat glands. Sweat glands are found in most regions of the skin. Who gets eccrine porocarcinoma poroma has also been found to occur in patients with other skin diseases, including hypohidrotic ectodermal dysplasia and Bowen's disease.7 Occasionally, a poroma may be found as a secondary lesion within a nevus sebac-eus.18 Eccrine porocarcinoma has a lower incidence than poroma and is estimated to constitute 0.005-0.01% of al

The clinicopathologic characteristics of 69 cases of eccrine porocarcinoma (EP) have been studied. Seven cases of purely in situ disease are included. Forty patients were female, 29 male with ages ranging from 29 to 91 years (mean 73 years). The lower extremity represented the single most common site (44%) (An immunohistochemical analysis of intraepithelial malignancies including Bowen's disease, Bowenoid actinic keratosis, malignant eccrine poroma, and Paget's disease using antibodies to cytokeratin (CK) 5/8, CK7, CK10, and CK19.) Barzi, AS, Ruggeri, S, Recchia, F, Bertoldi, I. Malignant metastatic eccrine poroma Eccrine poromas are rare, benign adnexal tumors derived from the intraepidermal portion of sweat ducts. Historically they were thought to arise from eccrine ducts although today it is thought that they may also have an apocrine origin. They usually appear as solitary, slow-growing, skin-colored papules on acral surfaces Eccrine poroma is a benign adnexal tumor that was first described by Pinkus et al in 1956. 1 It represents a small proportion of all sweat gland neoplasms and 0.0058% of epithelial skin tumors. 2 Eccrine porocarcinomas do exist and they are supposed to originate by malignant transformation of a poroma; however, 18% of poromas will actually progress to porocarcinomas in a mean of 8.5 years. The histological examination of the vulvectomy specimen resulted in eccrine porocarcinoma (EPC) diagnosis. A review of the literature disclosed eight vulvar cases previously reported. The study of the nine cases including the present revealed that the ages of the patients ranged from 32 to 88 years, with a mean of 66.1 years

Hashimoto K: The eccrine gland , in Jarrett A (ed): The Physiology and Pathology of the Skin. New York, Academic Press Inc, 1978, pp 1543-1573. New York, Academic Press Inc, 1978, pp 1543-1573. 26 Final pathologicalfindings were malignant eccrine poroma with close resected margin. There were no metastases in evidence from all investigations. Local irradiation with the aim of eradication of microscopically residual tumor was initiated. CONCLUSION: Malignant transformation is a rare occurrence of eccrine poroma A poroma is a benign adnexal neoplasm composed of epithelial cells that show tubular (usually distal ductal) differentiation. [] The malignant counterpart of a poroma is referred to as porocarcinoma. [] Poromas historically have been considered glandular adnexal neoplasms of eccrine lineage, and this view is so entrenched that the neoplasm is often referred to as eccrine poroma; however.

History Poromas typically are asymptomatic, slow-growing, or stable nodular lesions. [ 11] Although most are asymptomatic, pain can be a presenting sign. Poromas are one of many types of benign.. A variant with a Key Words: Eccrine porocarcinoma (malignant eccrine broad pushing tumor margin and marked nuclear pleomor- poroma)—Prognosis. phism showed some resemblance to proliferative bowenoid dysplasia. In 11 cases (18%) the tumors appeared to arise in Am J Surg Pathol 25 (6): 710-720, 2001. continuity with a benign preexistent poroma Poroma is a rare benign neoplasm that derives from eccrine sweat glands epithelium. Its histological subtypes, with respect to its position within skin layers, are eccrine poroma, hidroacanthoma simplex, poroid hidradenoma, and dermal duct tumor. Poromas commonly exhibit benign clinical behavior as they are usually small and asymptomatic and do not exhibit malignant behavior

Poroma is a rare benign tumor of the epidermal sweat duct unit with predilection for the head and neck. Only six cases with eyelid location have been described in the literature (PubMed). A 34-year-old male presented with a single tumor on the left upper eyelid. It was skin-colored, nodular, solid, tender with some telangiectatic vessels, and showed no ulcerated lesion Eccrine Poromatosis. From the Department of Medicine, Division of Dermatology, University of Maryland School of Medicine, Baltimore. A 65-year-old white woman had more than 100 eccrine poromas on her palms and soles. This is apparently the first recording of eccrine poromatosis Eccrine porocarcinoma was adapted as a nomenclature by Mishisma and Morikoin in 1969. The neoplasm is a malignant analogue of eccrine poroma which is a benign tumour of intra-dermal sweat glands. Eccrine porocarcinoma is an invasive malignancy of eccrine sweat gland with an acrosyringial genesis

Eccrine Poroma - an overview ScienceDirect Topic

Eccrine poroma (EP) is a benign sweat gland tumor comprising cells usually differentiating toward the intraepidermal portion of the eccrine sweat duct. First reported by Pinkus et al. in 1956 [ 1 ], these neoplastic growths are believed to comprise 10 percent of all sweat gland tumors, which of themselves represent only 1 percent of all primary. Vulvar eccrine porocarcinoma: report of a case and literature review. Val-Bernal JF (1), Hermana S. Author information: (1)Pathology Unit, Department of Medical and Surgical Sciences, University of Cantabria and IDIVAL, Santander, Spain; josefernando.val@scsalud.es. Adnexal carcinomas of the vulva are rare tumors Pathology notes Jun Wang, MD, PhD 1. General information Frequently discussed syndromes Terms of dermatology Terms of hematology 2 Pinkus H: Notes on the anatomy and pathology of the skin appendages: 1. The wall of the intraepidermal part of the sweat duct . J Invest Derm 2:175-186, 1939 Hashimoto K: The eccrine gland , in Jarrett A (ed): The Physiology and Pathology of the Skin. New York, Academic Press Inc, 1978, pp 1543-1573. New York, Academic Press Inc, 1978, pp 1543-1573. 26

Eccrine poroma: a clinical-dermoscopic study of seven case

A cutaneous glandular neoplasm. Eccrine or apocrine in origin. First described by Rulon and Helwig in 1977 ( Arch Dermatol 1977;113:596 ) A benign neoplasm (by some) and papillary adenocarcinoma in situ (by others) ( Dermatol Pract Concept 2014;4:23 ) May be an analogue of micropapillary ductal carcinoma in situ of the breast Eccrine poroma images. Created 2018. Eccrine poroma images — codes and concepts open > Go to the image library. Eccrine poroma. Eccrine poroma. Eccrine poroma. Eccrine poroma. Eccrine poroma. Eccrine poroma. Dermoscopy view. Eccrine poroma. Dermoscopy view of eccrine poroma (not histologically confirmed). • A 44-year-old woman had multiple papular lesions of 20 years' duration. The lesions were limited to the right lower extremity and were arranged in a linear fashion. They had the histologic appearance of eccrine poroma; however, thin intertwining strands of tumor cells extended down into the dermis.. Eccrine poroma is a rare tumor arising from sweat glands with common location being soles and palms. We are reporting a case of 70-year male patient with large lower lid mass lesion. Owing to its location and history of growth, malignancy was suspected. Biopsy proved it to be eccrine poroma which is a benign lesion Department of Pathology; University Hospital La Paz; Madrid, Spain The American Journal of Surgical Pathology: February 2002 - Volume 26 - Issue 2 - p 272-273 Bu

Eccrine Poroma - WebPatholog

A case of malignant eccrine poroma with lymph node metastases is described. The patient had a nodular growth of the right thigh 2 years before its first excision. Local recurrence in the scar occurred in 6 months, and by 8 months a right groin lymph node was involved Syringofibroadenoma is a benign adnexal tumour thought to be of eccrine origin, also named syringofibroadenoma of Mascaro, after the man who first described this tumour. It typically occurs on the extremities. Histology of syringofibroadenoma. Scanning power view of the histology of syringofibroadenoma reveals an epidermal proliferative process (Figure 1). ). Vertically oriented anastamosing.

Solitary eccrine syringofibroadenoma with nail involvement

Video: Poroma - Libre Patholog

A poroma is a benign adnexal neoplasm composed of epithelial cells that show tubular (usually distal ductal) differentiation. [] The malignant counterpart of a poroma is referred to as porocarcinoma. [] Poromas historically have been considered glandular adnexal neoplasms of eccrine lineage, and this view is so entrenched that the neoplasm is often referred to as eccrine poroma; however. Introduction. Eccrine hidrocystoma is a cystic lesion, thought to be derived from cystic retention of native eccrine glands.This entity has been challenged by some authorities who regard these as having an apocrine origin.. Histology of eccrine hidrocystoma. A cystic space occupies the dermis which may be unilocular (figure 1). The cystic space is lined by a thin epithelial layer consisting of. Sebaceous component were recognized in the presented three cases among the 62 cases (4.8%) examined in our department within the past 10 years. We also include a review of the 31 reported cases of poroma with sebaceous differentiation. None of them occurred in acral regions, where typical eccrine poromas predominate Hidroacanthoma simplex is a rare tumor and its histogenesis and classification have been the subject of discussion, especially as to its relation to eccrine poroma. The tumor in this study developed on the knee of an old woman as a Bowen's disease‐like lesion. Clinical and histological examinations confirmed the diagnosis of hidroacanthoma. Eccrine poroma is a benign neoplasm thought to differentiate toward the acrosyringeal portion of the sweat duct . Eccrine porocarcinoma is a rare malignancy of the eccrine sweat gland first described in 1963 by Pinkus and Mehregan . It has a propensity for lower extremity and a female predominance

Immunohistochemistry of eccrine poroma and porocarcinoma

  1. Eccrine poroma is a benign tumor which arises from the intraepidermal portion of the eccrine sweat glands. It usually occurs as a solitary lesion in the extremity, with the foot and sole as a common site. It may present as a foot mass, ulcerative lesion, bleeding lesion, or suspected melanoma. The clinical diagnosis is often delayed or inaccurate
  2. Three subtypes of poroid neoplasia in a single lesion: eccrine poroma, hidroacanthoma simplex, and dermal duct tumor. Histologic, histochemical, and ultrastructural findings. Am J Dermatopathol . 1994 Feb. 16(1):66-72
  3. De novo malignant eccrine spiradenoma: a case report and review of the literature. Dermatol Surg. vol. 32. 2006. pp. 1189-98. (A case report of malignant eccrine spiradenoma arising on the forehead over a period of 1 week. This is unusual since most malignant eccrine spiradenomas arise within a preexisting benign spiradenoma
  4. This is a benign sweat duct tumor, in this case, a poroma (por - duct, oma - tumor).Acrospiroma = Benign Sweat Duct Tumor:Benign sweat duct tumors are derive..
  5. Eccrine sweat gland carcinoma (ESGC): ICD-10-CM L74.9; Disease. Humans have the highest density of eccrine sweat glands of any mammal. Eccrine sweat glands (ESG) arise from ectodermal appendages and can be found in differential densities throughout the human body
  6. Background: There are no immunohistochemical studies on cytokeratin (CK) expression in large series of cases of apocrine poroma. In addition, detailed immunohistochemical analysis of cuticular cells, a specific type of constituent cells of poromas, has not been reported. Methods: Using the avidin‐biotin method, we compared immunostaining patterns of eleven different anti‐CK antibodies in.
  7. DOI: 10.1111/cup.13559 Corpus ID: 199449485. Reactive epidermal eccrine proliferation on the foot due to lymphedema: Eccrine poroma or syringofibroadenoma? @article{Hafeez2019ReactiveEE, title={Reactive epidermal eccrine proliferation on the foot due to lymphedema: Eccrine poroma or syringofibroadenoma?}, author={F. Hafeez}, journal={Journal of Cutaneous Pathology}, year={2019}, volume={46}

Poroma (Eccrine Poroma, Hidroacanthoma Simplex, Dermal

Sweat gland lesions DermNet N

Poroma and Dermal Duct Tumor David Cassarino, MD, PhD Key Facts Terminology Eccrine poroma Apocrine poroma Hidroacanthoma simplex (intraepidermal poroma, syringoacanthoma) Acrospiroma (older term, includes poroma and hidradenoma) Benign adnexal proliferation with anastomosing cords of cells and ductal differentiation Clinical Issues Relatively common tumors Usually occur in middle-aged adults. Given the evidence of sebaceous and follicular differentiation seen in this study and the common embryologic origin of follicular, sebaceous, and apocrine structures, it follows that at least some benign neoplastic proliferations with histopathologic features of eccrine poroma could be of apocrine origin. From MEDLINE®/PubMed®, a database. Eccrine porocarcinoma (EPC) is a potentially lethal neoplasm of the skin that arises from the intraepidermal portion of the eccrine sweat glands. It was previously known as eccrine adenocarcinoma or malignant eccrine poroma. It commonly occurs between 60 to 80 years of age, usually arising from hands and feet

Poroma - an overview ScienceDirect Topic

Webpathology

Porocarcinoma - Libre Patholog

Pinkus initially described eccrine poroma as a benign neoplasm of the acrosyringium. The tumor, often consisting of broad anastamosing bands, arises from the epidermis and extends downward into the dermis. However, it may be completely intraepidermal (hidroacanthoma simplex), and, at times, appear to be completely dermal (dermal duct tumor). The characteristic tumor cell is. Al-Qattan MM: Eccrine spiradenoma of the hand clinically mimicking a lipoma. J Hand Surg 21B:551-2,1996. Buckley RC, Kanosky MG, Songcharoen S: Eccrine poroma in the palm of the hand. J Hand Surg 18A:609-11,1993. Fahy AM, Peters EE: Eccrine tumours of the hand: two cases. J Hand Surg 12B:120-2,1987 UCLA Department of Pathology Introduction: • Cutaneous adnexal neoplasms (CANs) are a diverse group of tumors that derive from either the folliculo-sebaceous/apocrine unit or the eccrine glands • Occasionally, these neoplasms display more than one line of differentiatio Eccrine porocarcinoma is a rare malignancy of the eccrine sweat gland. It is usually found frequently on the lower extremities, and it affects both sexes equally usually in the sixth to seventh decade. In our case, we present a 42-year-old male patient with a recurring exophytic tumor on the right lower extremity without local extension. The initial tumor was biopsied, excised and diagnosed as.

Eccrine & Apocrine Tumors - WebPatholog

University oi Pennsylvania School of Medicine. Philadelphia, Pennsylvania, and the Department oi Pathology, Northeastern Hospital. Philadelphia. Pennsylvania Discussion Pinkus described eccrine poroma in 195b as a tumor derived from the acrosyringium or intraepidermal portion of the eccrine sweat duct unit. Eccrine porocarcinoma is an invasive carcinoma of the eccrine sweat glands, with an acrosyringeal origin. Other names were epidermotropic eccrine carcinoma, poroepithelioma, malignant hidroacanthoma simplex, malignant intraepidermal eccrine poroma, malignant eccrine poroma, malignant syringo-acanthoma and dysplastic poroma Eccrine carcinoma (EC) is a rare carcinoma that originates from the eccrine sweat glands of the skin and accounts for less than 0.01% of diagnosed cutaneous malignancies. [1] Sweat gland tumors have traditionally subdivided into four broad groups: eccrine, apocrine, mixed origin (eccrine and apocrine), and other unclassifiable sweat gland tumors Eccrine spiradenoma. H&E stain. Synonyms. spiradenoma. LM. dense nests of cells in the dermis (dermal blue balls), mixed cell population (epithelial, myoepithelial, +/-lymphocytes) LM DDx. dermal cylindroma, trichoepithelioma. IHC Eccrine poroma is a benign adnexal tumour of the uppermost portion of the intra-epidermal eccrine duct and the acrosyringium. Malignant eccrine poroma was first described in 1963 by Pinkus and Mehregan, using the term epidermotropic eccrine carcinoma (Pinkus and Mehregan 1963).It is regarded as the rare malignant counterpart of eccrine poroma, a benign tumour of the intraepidermal eccrine.

Pathology Eccrine poroma, which originates from the intraepi- dermal sweat gland represents 10% of all sweat gland turn or^.^ It commonly occurs on the palms of the hands and the soles of the feet and usually is soli- FIGURE growth pattern is shown (H ii E stain, ~100). 6. Porocarcinoma with adjacent syringofibroadenoma-lik Eccrine porocarcinoma is a rare cancer and so can sometimes be difficult to diagnose. Diagnosis is usually made with a skin biopsy of the affected area where a small sample of tissue is taken so that it can be examined under a microscope. The pathologist who examines this sample will look for the characteristic features of. Eccrine poroma is a benign adnexal neoplasm that clinically may mimic malignant skin tumors such as squamous cell carcinoma and amelanotic melanoma. The dermoscopic features of pigmented and nonpigmented eccrine poroma have recently been described. We present 2 cases of eccrine poroma, with their dermoscopic features. The lesions were characterized by multiple red lacunes and a polymorphous. Porocarcinoma (or eccrine porocarcinoma) is a rare type of malignant eccrine sweat gland tumor, more frequently encountered in the lower extremities (feet and legs).It arises from the intraepidermal portion of eccrine sweat glands or acrosyringium. It represents 0.005-0.01% of all cutaneous tumors.Even though it rarely metastasizes, 20% of patients with a porocarcinoma will present with. Eccrine carcinoma is a rare skin condition characterized by a plaque or nodule on the scalp, trunk, or extremities.: 669 It originates from the eccrine sweat glands of the skin, accounting for less than 0.01% of diagnosed cutaneous malignancies. Eccrine carcinoma tumors are locally aggressive with a high rate of recurrence. Lack of reliable immunohistochemical markers and similarity to other.

Pathology Outlines - Eccrine spiradenomaPoroma of the hip and buttock

Eccrine Poroma: One Tumor, Many Faces - Forman - 2005

could have arisen from a preexisting benign eccrine poroma. Regional lymph node metastases are found in about 20% of patients, and distant metastases arise in about 10% of patients.4-5,8 The disease may appear nodular, infiltrative, ulcerated or polypoid. Multinodularity, ulceration and rapid growth ma Eccrine porocarcinoma is a rare malignant tumor that develops in the eccrine glands, appearing as a primary tumor, or by malignant transformation of an eccrine poroma. It is a carcinoma with high metastatic and recurrent potential; it has the same incidence in both sexes, and mainly affects the elderly. Its diagnosis, rather than clinical, is histological, and due to the rarity of the disease.

Eccrine porocarcinoma DermNet N

Malignant eccrine tumors generally present as a single, asymptomatic, nondescript cutaneous lesion. Eccrine carcinomas account for less than 0.01% of all cutaneous appendageal carcinomas. [] The most commonly affected age group is those in their seventh decade of life, and it equally affects men and women Chang O, Elnawawi A, Rimpel B, Asarian A, Chaudhry N. Eccrine porocarcinoma of the lower extremity: a case report and review of literature. World J Surg Oncol. 2011 Aug 22. 9:94. . . Kang MC, Kim SA, Lee KS, Cho JW. A case of an unusual eccrine poroma on the left forearm area. Ann Dermatol. 2011 May. 23(2):250-3.

Epidermal Neoplasms pathology - Dermatology 101 with Other

Poroma: a review of eccrine, apocrine, and malignant form

Background. A poroma is a benign adnexal neoplasm composed of epithelial cells that show tubular (usually distal ductal) differentiation. [1] The malignant counterpart of a poroma is referred to as porocarcinoma. [2] Poromas historically have been considered glandular adnexal neoplasms of eccrine lineage, and this view is so entrenched that the neoplasm is often referred to as eccrine poroma. Eccrine poroma; apocrine poroma; juxtaepidermal poroma; hidroacanthoma simplex; dermal duct tumor Definition Adnexal neoplasm composed of benign epithelial cells that show tubular (usually ductal) differentiation of either eccrine or apocrine lineag The initial histopathologic diagnosis was coexistent eccrine poroma and basal cell epithelioma, but reexamination led to the conclusion that it was the complex poroma‐like adnexal adenoma like that described by Hanau et al. in 1984 and Requena et al. in 1998. In histologic detail, the lesion exhibited combined adnexal differentiation ( Fig. 2 )

Chapter 5: Sweat Gland Neoplasms - Medicine 101 with A at

Eccrine Porocarcinoma (Malignant Eccrine Poroma): A

Poroma of the hip and buttock Deba P Sarma MD 1, Sadiq U Zaman MD 1, Eric E Santos MD 2, James M Shehan MD 3 Dermatology Online Journal 15 (5): 10 1. Department of Pathology, Creighton University Medical Center, Omaha, Nebraska 2, St. Margaret's Hospital, Spring Valley, Illinois 3. Department of Medicine, Division of Dermatology, Creighton University Medical Center, Omaha, Nebraska. jimshehan. title = Holocrine Poroma: A Distinctive Adnexal Tumor, abstract = There are 36 cases of complex poroid tumors with folliculosebaceous and apocrine differentiation reported in the literature. The authors evaluated 111 poroid tumors including 63 typical eccrine poromas and 48 poroid tumors with folliculosebaceous elements Like other tumors of skin adnexa, malignant eccrine poroma is a rare tumor. It mostly affects older persons. Clinical diagnosis is difficult, and lesions are often mistakenly identified as squamous cell carcinoma or pyogenic granuloma. We report a case of malignant eccrine poroma invading the parotid gland

Eccrine poroma. Eccrine poroma is a benign tumor that typically occurs on the palms and soles. [ 127] This lesion is superficial and arises within the epidermis, with sharply demarcated borders. Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. The American journal of surgical pathology, 25(6), 710-720. PINKUS, H., & MEHREGAN, A. H. (1963). Epidermotropic eccrine carcinoma: a case combining features of eccrine poroma and Paget's dermatosis. Archives of dermatology, 88(5), 597-606 Poroma is a benign skin tumor exhibiting terminal sweat gland duct differentiation. The present study aimed to explore the potential role of gene fusions in the tumorigenesis of poromas. RNA sequencing and reverse transcription PCR identified highly recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poromas (92/104 lesions, 88.5%) and their rare. Eccrine porocarcinoma (EPC) was first described by Pinkus & Mehregan in 1963 (1) as epidermotropic eccrine carcinoma and is the malignant counterpart of eccrine poroma. It is a rare tumour (0.005-0.01% (2, 3) of cutaneous tumours), thought to arise from the acrosyringium of the sweat gland of the skin We describe a novel monoclonal antibody IKH-4 which stains the eccrine secretory coil, but not the apocrine secretory segment. Positive staining was observed in eccrine hidradenoma, eccrine poroma, eccrine spiradenoma, papillary eccrine adenoma, eccrine hidrocystoma, syringoma, eccrine carcinoma, and in 1 case of syringocystadenoma papilliferum METHODS: The results are presented on the basis of the clinical case of a malignant eccrine poroma with metastatic regional lymph nodes. RESULTS: With our new chemotherapeutic protocol, arrest of the metastatic progression was achieved after 3 months and the remission was maintained until the 10th month of therapy